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Thus, we can argue that one important role that the peroxisome plays is to extract deupleted protons from solution and deliver them to the mitochondria, and, ultimately, to the ATPase pumps, in the form of H 2 O 2

In the APP (Swe)/[PS1(L166P)] transgenic (Tg) model of AD, germ-free status reduced cerebral A load compared to conventionally raised APP rodents (Harach et al., 2017), implicating microbiota as a direct or indirect modifier of peripheral amyloidosis (discussed later in Section Gut Microbiome-Mediated Fibril Formation)

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